Gene

notch1b

ID

ZDB-GENE-990415-183

Name

notch receptor 1b

Symbol

notch1b Nomenclature History

Previous Names

etID309871.5 (1)
wu:fc55e11

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity and signaling receptor activity. Involved in several processes, including fin regeneration; nervous system development; and vasculature development. Predicted to localize to plasma membrane and protein-containing complex. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia; and aortic valve disease 1. Is expressed in several structures, including cardiovascular system; digestive system; hematopoietic multipotent progenitor cell; nervous system; and trunk. Orthologous to human NOTCH1 (notch receptor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

170 figures from 115 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu523 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 14 figures from 12 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With notch1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Adams-Oliver syndrome	Alliance	Adams-Oliver syndrome 5	616028
aortic valve disease 1	Alliance	Aortic valve disease 1	109730

Associated With notch1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR013032	EGF-like, conserved site
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR000800	Notch domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR010660	Notch, NOD domain
Domain	IPR011656	Notch, NODP domain
Domain	IPR024600	Notch, C-terminal
Family	IPR008297	Notch
Family	IPR022362	Neurogenic locus notch homolog protein 1
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR035993	Notch-like domain superfamily
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site
Repeat	IPR002110	Ankyrin repeat