lrrc7

ID

ZDB-GENE-130530-876

Name

leucine rich repeat containing 7

Symbol

lrrc7 Nomenclature History

Previous Names

zmp:0000000873 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable protein kinase binding activity. Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; neurotransmitter receptor transport, endosome to postsynaptic membrane; and receptor clustering. Predicted to be located in cytoplasm and dendritic spine. Predicted to be active in adherens junction; basolateral plasma membrane; and postsynaptic density. Predicted to colocalize with postsynaptic membrane. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 77 and cocaine dependence. Orthologous to human LRRC7 (leucine rich repeat containing 7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lrrc7 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant intellectual developmental disorder 77	Alliance	Intellectual developmental disorder, autosomal dominant 77	621415

Associated With lrrc7 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001478	PDZ domain
Domain	IPR055414	Disease resistance R13L4/SHOC-2-like, LRR domain
Family	IPR050614	Synaptic Scaffolding LAP/MAGUK Families
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M3BAF2	InterPro	1500
UniProtKB:A0A8M2BDE2	InterPro	1548
UniProtKB:A0A8M3ATF9	InterPro	1499
UniProtKB:A0A8M2BDA7	InterPro	1554
UniProtKB:A0A8M3B0I0	InterPro	1537
UniProtKB:A0A8M2BDI3	InterPro	1506
UniProtKB:A0A8M2BDH3	InterPro	1556
UniProtKB:A0A8M2BDC0	InterPro	1527
UniProtKB:A0A8M2BDA8	InterPro	1550
UniProtKB:A0AB32TWG1	InterPro	1543
UniProtKB:A0AC58JUX6	InterPro	1493
UniProtKB:A0AC58JUX8	InterPro	1508
UniProtKB:A0AC58JUY0	InterPro	1537
UniProtKB:A0AC58JUY5	InterPro	1495
UniProtKB:A0AC58JUY6	InterPro	1489
UniProtKB:A0AC58JUY8	InterPro	1487
UniProtKB:A0AC58JUY9	InterPro	1514
UniProtKB:A0AC58JUZ1	InterPro	1464
UniProtKB:A0AC58JUZ2	InterPro	1470
UniProtKB:A0AC58JUZ4	InterPro	1470
UniProtKB:A0AC58JUZ5	InterPro	1477
UniProtKB:A0AC58JUZ6	InterPro	1480
UniProtKB:A0AC58JUZ7	InterPro	1487
UniProtKB:A0AC58JUZ8	InterPro	1497
UniProtKB:A0AC58JUZ9	InterPro	1493
UniProtKB:A0AC58JV02	InterPro	1458
UniProtKB:A0AC58JV03	InterPro	1458
UniProtKB:A0AC58JV04	InterPro	1480
UniProtKB:A0AC58JV06	InterPro	1420
UniProtKB:A0AC58JV08	InterPro	1430
UniProtKB:A0AC58JV10	InterPro	1474
UniProtKB:A0AC58JV11	InterPro	1407
UniProtKB:A0AC58JV12	InterPro	1436
UniProtKB:A0AC58JV13	InterPro	1457
UniProtKB:A0AC58JV14	InterPro	1468
UniProtKB:A0AC58JV15	InterPro	1497
UniProtKB:A0AC58JV16	InterPro	1521
UniProtKB:A0AC58JV17	InterPro	1493
UniProtKB:A0AC58JV19	InterPro	1443
UniProtKB:A0AC58JV20	InterPro	1449
UniProtKB:A0AC58JV25	InterPro	1436
UniProtKB:A0AC58JV29	InterPro	1464
UniProtKB:A0AC58JV31	InterPro	1484
UniProtKB:A0AC58JV36	InterPro	1420
UniProtKB:A0AC58JV39	InterPro	1535
UniProtKB:A0AC58JV45	InterPro	1401
UniProtKB:A0AC58JV47	InterPro	1430
UniProtKB:A0AC58JV48	InterPro	1449
UniProtKB:A0AC58JV55	InterPro	1486
UniProtKB:A0AC58JV70	InterPro	1451