Gene

pik3ca

ID
ZDB-GENE-130409-1
Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Symbol
pik3ca Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have 1-phosphatidylinositol-3-kinase activity; ATP binding activity; and phosphatidylinositol bisphosphate kinase activity. Involved in regulation of collateral sprouting in absence of injury. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome; breast cancer (multiple); colorectal cancer (multiple); and cutaneous Paget's disease. Is expressed in eye. Orthologous to human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Schmidt et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pik3ca Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
breast cancer Alliance Breast cancer, somatic 114480
CLOVES syndrome Alliance CLOVE syndrome, somatic 612918
colorectal cancer Alliance Colorectal cancer, somatic 114500
Cowden syndrome 5 Alliance Cowden syndrome 5 615108
epidermal nevus Alliance Nevus, epidermal, somatic 162900
hepatocellular carcinoma Alliance Hepatocellular carcinoma, somatic 114550
lung cancer Alliance Nonsmall cell lung cancer, somatic 211980
ovarian cancer Alliance Ovarian cancer, somatic 167000
seborrheic keratosis Alliance Keratosis, seborrheic, somatic 182000
stomach cancer Alliance Gastric cancer, somatic 613659
Cerebral cavernous malformations 4, somatic 619538
CLAPO syndrome, somatic 613089
Hemifacial myohyperplasia, somatic 606733
Macrodactyly, somatic 155500
Megalencephaly-capillary malformation-polymicrogyria syndrome, somatic 602501
Associated With pik3ca Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
Domain IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
Domain IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
Domain IPR002420 C2 phosphatidylinositol 3-kinase-type domain
Domain IPR003113 Phosphatidylinositol 3-kinase, adaptor-binding domain
Family IPR015433 Phosphatidylinositol kinase
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Homologous_superfamily IPR035892 C2 domain superfamily
Homologous_superfamily IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Homologous_superfamily IPR042236 Phosphoinositide 3-kinase, accessory (PIK) domain superfamily
Domain Details Per Protein
Protein Length Armadillo-type fold C2 domain superfamily C2 phosphatidylinositol 3-kinase-type domain Phosphatidylinositol 3-/4-kinase, catalytic domain Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily Phosphatidylinositol 3/4-kinase, conserved site Phosphatidylinositol 3-kinase, adaptor-binding domain Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain Phosphatidylinositol kinase Phosphoinositide 3-kinase, accessory (PIK) domain Phosphoinositide 3-kinase, accessory (PIK) domain superfamily Protein kinase-like domain superfamily Ubiquitin-like domain superfamily
UniProtKB:F1QAD7
InterPro
1069
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA pik3ca-202 (1)
Ensembl
Havana 4279 nt
ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations
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