ZFIN is now using GRCz12tu for Genomic Data
Gene
mocs1
- ID
- ZDB-GENE-130215-1
- Name
- molybdenum cofactor synthesis 1
- Symbol
- mocs1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable GTP 3',8'-cyclase activity and cyclic pyranopterin monophosphate synthase activity. Predicted to be involved in Mo-molybdopterin cofactor biosynthetic process. Predicted to be located in mitochondrial matrix. Human ortholog(s) of this gene implicated in molybdenum cofactor deficiency type A. Orthologous to human MOCS1 (molybdenum cofactor synthesis 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| molybdenum cofactor deficiency type A | Alliance | Molybdenum cofactor deficiency A | 252150 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000385 | MoaA/NifB/PqqE, iron-sulphur binding, conserved site |
| Domain | IPR002820 | Molybdopterin cofactor biosynthesis C (MoaC) domain |
| Domain | IPR006638 | Elp3/MiaA/NifB-like, radical SAM core domain |
| Domain | IPR007197 | Radical SAM |
| Domain | IPR010505 | Molybdenum cofactor biosynthesis protein A-like, twitch domain |
| Family | IPR013483 | Molybdenum cofactor biosynthesis protein A |
| Family | IPR023045 | Molybdenum cofactor biosynthesis C |
| Family | IPR040064 | Molybdenum cofactor biosynthesis protein A-like |
| Family | IPR047594 | Molybdenum cofactor biosynthesis C, bacteria/eukaryotes |
| Family | IPR050105 | Molybdenum cofactor biosynthesis MoaA/MoaC |
| Homologous_superfamily | IPR013785 | Aldolase-type TIM barrel |
| Homologous_superfamily | IPR036522 | Molybdopterin cofactor biosynthesis C (MoaC) domain superfamily |
| Homologous_superfamily | IPR058240 | Radical SAM superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Aldolase-type TIM barrel | Elp3/MiaA/NifB-like, radical SAM core domain | MoaA/NifB/PqqE, iron-sulphur binding, conserved site | Molybdenum cofactor biosynthesis C | Molybdenum cofactor biosynthesis C, bacteria/eukaryotes | Molybdenum cofactor biosynthesis MoaA/MoaC | Molybdenum cofactor biosynthesis protein A | Molybdenum cofactor biosynthesis protein A-like | Molybdenum cofactor biosynthesis protein A-like, twitch domain | Molybdopterin cofactor biosynthesis C (MoaC) domain | Molybdopterin cofactor biosynthesis C (MoaC) domain superfamily | Radical SAM | Radical SAM superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AJ79 | InterPro | 734 | |||||||||||||
| UniProtKB:F1R905 | InterPro | 402 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance