Gene

brsk1a

ID

ZDB-GENE-121214-354

Name

BR serine/threonine kinase 1a

Symbol

brsk1a Nomenclature History

Previous Names

si:ch211-255p10.4

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Orthologous to human BRSK1 (BR serine/threonine kinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa22011	Allele with one point mutation	Unknown	Splice Site	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa35198	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With brsk1a Human Ortholog

No data available

Associated With brsk1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR048622	BRSK1/2-like, UBA domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

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Domain Details Per Protein

Protein	Length	BRSK1/2-like, UBA domain	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site
UniProtKB:A0A8M6Z1D7 InterPro	739
UniProtKB:A0A8N7UT72 InterPro	746

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Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 12

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	si:ch211-255p10.4-201 (1) Ensembl	Ensembl	2,539 nt	Select Tool ZFIN BLAST
mRNA	si:ch211-255p10.4-202 (1) Ensembl	Ensembl	543 nt	Select Tool ZFIN BLAST
mRNA	si:ch211-255p10.4-203 (1) Ensembl	Ensembl	1,296 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH211-255P10	AL935197	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_688031 (1)	4285 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:AL935197 (1)	193113 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A8N7UT72 (1)	746 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	BRSK1	19	Ensembl:ENSG00000160469 Gene:84446 OMIM:609235 HGNC:18994	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)
Mouse	Brsk1	7	Ensembl:ENSMUSG00000035390 MGI:2685946 Gene:381979	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)

Citations

Include unpublished citations

Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613

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