Gene
mast1a
- ID
- ZDB-GENE-121214-221
- Name
- microtubule associated serine/threonine kinase 1a
- Symbol
- mast1a Nomenclature History
- Previous Names
-
- si:ch211-212h16.3
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Predicted to be involved in cytoskeleton organization; intracellular signal transduction; and peptidyl-serine phosphorylation. Human ortholog(s) of this gene implicated in mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations. Orthologous to human MAST1 (microtubule associated serine/threonine kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations | Alliance | Mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations | 618273 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR015022 | Microtubule-associated serine/threonine-protein kinase, pre-PK domain |
| Domain | IPR037711 | Microtubule-associated serine/threonine-protein kinase, catalytic domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR023142 | Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
Domain Details Per Protein
| Protein | Length | AGC-kinase, C-terminal | Microtubule-associated serine/threonine-protein kinase, catalytic domain | Microtubule-associated serine/threonine-protein kinase, pre-PK domain | Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily | PDZ domain | PDZ superfamily | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AKH8
|
1738 | |||||||||
|
UniProtKB:E7F0L8
|
1717 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
mast1a-201
(1)
|
Havana | 5154 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance