Gene
bicd2
- ID
- ZDB-GENE-120717-1
- Name
- bicaudal D homolog 2 (Drosophila)
- Symbol
- bicd2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable dynactin binding activity and dynein complex binding activity. Acts upstream of or within heart contraction. Predicted to be active in Golgi apparatus and cytosol. Is expressed in forebrain; heart; hindbrain; midbrain; and pectoral fin bud. Human ortholog(s) of this gene implicated in spinal muscular atrophy with lower extremity predominant 2A and spinal muscular atrophy with lower extremity predominant 2B. Orthologous to human BICD2 (BICD cargo adaptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Luo et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spinal muscular atrophy with lower extremity predominant 2A | Alliance | Spinal muscular atrophy, lower extremity-predominant, 2A, autosomal dominant | 615290 |
| spinal muscular atrophy with lower extremity predominant 2B | Alliance | Spinal muscular atrophy, lower extremity-predominant, 2B, autosomal dominant | 618291 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR018477 | Bicaudal-D protein |
Domain Details Per Protein
| Protein | Length | Bicaudal-D protein |
|---|---|---|
|
UniProtKB:X1WDT9
|
846 | |
|
UniProtKB:A0A8N7TEB8
|
809 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance