Gene

trpm2

ID

ZDB-GENE-061214-4

Name

transient receptor potential cation channel, subfamily M, member 2

Symbol

trpm2 Nomenclature History

Previous Names

si:ch73-263b18.1

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Exhibits calcium ion binding activity; ligand-gated calcium channel activity; and mono-ADP-D-ribose binding activity. Involved in calcium ion transmembrane transport and protein homotetramerization. Localizes to integral component of plasma membrane. Is expressed in integument; keratinocyte; nervous system; and solid lens vesicle. Orthologous to human TRPM2 (transient receptor potential cation channel subfamily M member 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With trpm2 Human Ortholog

No data available

Associated With trpm2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005821	Ion transport domain
Domain	IPR041491	TRPM, SLOG domain
Homologous_superfamily	IPR015797	NUDIX hydrolase-like domain superfamily

Domain Details Per Protein

Protein	Length	Ion transport domain	NUDIX hydrolase-like domain superfamily	TRPM, SLOG domain
UniProtKB:A0A5H1ZRI9 InterPro	197
UniProtKB:S5TZ89 InterPro	1470
UniProtKB:A0A0R4IMY7 InterPro PDB	1470
UniProtKB:A0A8M9Q4R1 InterPro	1513
UniProtKB:A0A8M9QAZ3 InterPro	1398
UniProtKB:A0A8M3AWC9 InterPro	1474