Gene

kalrna

ID

ZDB-GENE-100921-4

Name

kalirin RhoGEF kinase a

Symbol

kalrna Nomenclature History

Previous Names

si:dkey-275m12.1

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to enable guanyl-nucleotide exchange factor activity and nucleotide binding activity. Acts upstream of or within hemopoiesis. Predicted to be located in cytoplasm. Is expressed in head. Orthologous to human KALRN (kalirin RhoGEF kinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Sarangdhar et al., 2017

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Bielczyk-Maczyńska et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kalrna Human Ortholog

No data available

Associated With kalrna Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR000719	Protein kinase domain
Domain	IPR001251	CRAL-TRIO lipid binding domain
Domain	IPR001452	SH3 domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR003961	Fibronectin type III
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Domain	IPR028570	Kalirin/Triple functional domain protein, SH3 domain 1
Domain	IPR047053	Kalirin/Triple functional domain protein, SH3 domain 2
Domain	IPR047054	Kalirin/Triple functional domain protein, pleckstrin homology (PH) domain 1
Family	IPR051336	Rho GTPase-activating Guanine Nucleotide Exchange Factors
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036116	Fibronectin type III superfamily
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily
Homologous_superfamily	IPR036865	CRAL-TRIO lipid binding domain superfamily
Repeat	IPR002017	Spectrin repeat
Repeat	IPR018159	Spectrin/alpha-actinin

Domain Details Per Protein

Protein	Length	CRAL-TRIO lipid binding domain	CRAL-TRIO lipid binding domain superfamily	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	Fibronectin type III	Fibronectin type III superfamily	Immunoglobulin domain subtype	Immunoglobulin I-set	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin subtype 2	Kalirin/Triple functional domain protein, pleckstrin homology (PH) domain 1	Kalirin/Triple functional domain protein, SH3 domain 1	Kalirin/Triple functional domain protein, SH3 domain 2	PH-like domain superfamily	Pleckstrin homology domain	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Rho GTPase-activating Guanine Nucleotide Exchange Factors	Serine/threonine-protein kinase, active site	SH3 domain	SH3-like domain superfamily	Spectrin/alpha-actinin	Spectrin repeat
UniProtKB:A0A8M3BC94 InterPro	1283
UniProtKB:A0A8M3B5D5 InterPro	2967
UniProtKB:A0A8M9QFR7 InterPro	2966
UniProtKB:A0A8M3AVQ1 InterPro	1353
UniProtKB:A0A8M3B2F5 InterPro	2936
UniProtKB:A0A8M6Z2L7 InterPro	2968

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	kalrna-201 (1) Ensembl	Ensembl	4,899 nt	Select Tool ZFIN BLAST
mRNA	kalrna-202 (1) Ensembl	Ensembl	7,269 nt	Select Tool ZFIN BLAST
mRNA	kalrna-203 (1) Ensembl	Ensembl	2,696 nt	Select Tool ZFIN BLAST
mRNA	kalrna-204 (1) Ensembl	Ensembl	2,328 nt	Select Tool ZFIN BLAST
mRNA	kalrna-205 (1) Ensembl	Ensembl	2,165 nt	Select Tool ZFIN BLAST
mRNA	kalrna-206 (1) Ensembl	Ensembl	906 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations