Gene

grb10b

ID

ZDB-GENE-091020-12

Name

growth factor receptor-bound protein 10b

Symbol

grb10b Nomenclature History

Previous Names

si:ch211-149m3.3

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to enable insulin receptor binding activity. Predicted to be involved in insulin receptor signaling pathway; negative regulation of Wnt signaling pathway; and negative regulation of insulin receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in cytoplasm. Orthologous to human GRB10 (growth factor receptor bound protein 10).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With grb10b Human Ortholog

No data available

Associated With grb10b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000159	Ras-associating domain
Domain	IPR000980	SH2 domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR015042	BPS (Between PH and SH2) domain
Domain	IPR035037	Grb10, SH2
Domain	IPR039665	APBB1IP, PH domain
Family	IPR039664	GRB/APBB1IP
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR036860	SH2 domain superfamily

Domain Details Per Protein

Protein	Length	APBB1IP, PH domain	BPS (Between PH and SH2) domain	Grb10, SH2	GRB/APBB1IP	PH-like domain superfamily	Pleckstrin homology domain	Ras-associating domain	SH2 domain	SH2 domain superfamily	Ubiquitin-like domain superfamily
UniProtKB:A0A8M2B462 InterPro	444
UniProtKB:F1QSC3 InterPro	594
UniProtKB:A0A8M9P869 InterPro	595

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	grb10b-201 (1) Ensembl	Ensembl		5,586 nt	Select Tool ZFIN BLAST
ncRNA	grb10b-002 (1) Ensembl	Ensembl		1,382 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations