Gene

nlgn4xb

ID
ZDB-GENE-100309-1
Name
neuroligin 4 X-linked b
Symbol
nlgn4xb Nomenclature History
Previous Names
  • nlgn4a (1)
  • nlgn4b
Type
protein_coding_gene
Location
Ambiguous Mapping Details/Browsers
Description
Predicted to enable neurexin family protein binding activity. Predicted to act upstream of or within cell adhesion. Predicted to be located in membrane. Is expressed in several structures, including brain; cranial ganglion; eye; gonad; and swim bladder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human NLGN4X (neuroligin 4 X-linked).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
No data available
Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-nlgn4xb
    		 (2)
    1 - 1 of 1
    Show
    Human Disease
    Associated With nlgn4xb Human Ortholog
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Intellectual developmental disorder, X-linked 300495
    {Autism susceptibility, X-linked 2} 300495
    1 - 2 of 2
    Associated With nlgn4xb Via Experimental Models
    No data available
    Gene Ontology
    Protein Domains
    Domain, Family, and Site Summary
    Type InterPro ID Name
    Conserved_site IPR019819 Carboxylesterase type B, conserved site
    Domain IPR002018 Carboxylesterase, type B
    Family IPR000460 Neuroligin
    Family IPR051093 Neuroligin and Bile salt-activated lipase
    Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
    1 - 5 of 5
    Domain Details Per Protein
    Protein Length Alpha/Beta hydrolase fold Carboxylesterase, type B Carboxylesterase type B, conserved site Neuroligin Neuroligin and Bile salt-activated lipase
    UniProtKB:F1QK81
    InterPro
    		795
    UniProtKB:D0EVX3
    InterPro
    		795
    1 - 2 of 2
    Transcripts
    Genome Browsers
    Type Name Annotation Method Has Havana Data Length (nt) Analysis
    mRNA nlgn4xb-201 (1)
    Ensembl
    		Ensembl 2,900 nt
    ZFIN BLAST
    mRNA nlgn4xb-202 (1)
    Ensembl
    		Ensembl 2,679 nt
    ZFIN BLAST
    mRNA nlgn4xb-203 (1)
    Ensembl
    		Ensembl 2,880 nt
    ZFIN BLAST
    1 - 3 of 3
    Interactions and Pathways
    No data available
    Antibodies
    No data available
    Plasmids
    No data available
    Constructs
    No data available
    Marker Relationships
    No data available
    Sequences
    Orthology
    Comparative Orthology
    Alliance
    Gene Tree
    Ensembl
    Citations
    Your Input Welcome
    We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.