Gene
usp45
- ID
- ZDB-GENE-100211-2
- Name
- ubiquitin specific peptidase 45
- Symbol
- usp45 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have thiol-dependent ubiquitinyl hydrolase activity and zinc ion binding activity. Involved in photoreceptor cell maintenance. Localizes to photoreceptor inner segment. Human ortholog(s) of this gene implicated in Leber congenital amaurosis. Orthologous to human USP45 (ubiquitin specific peptidase 45).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Leber congenital amaurosis 19 | Alliance | ?Leber congenital amaurosis 19 | 618513 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018200 | Ubiquitin specific protease, conserved site |
| Domain | IPR001394 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase |
| Domain | IPR001607 | Zinc finger, UBP-type |
| Domain | IPR028889 | Ubiquitin specific protease domain |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Length | Papain-like cysteine peptidase superfamily | Peptidase C19, ubiquitin carboxyl-terminal hydrolase | Ubiquitin specific protease, conserved site | Ubiquitin specific protease domain | Zinc finger, RING/FYVE/PHD-type | Zinc finger, UBP-type |
|---|---|---|---|---|---|---|---|
|
UniProtKB:E9QG68
|
803 | ||||||
|
UniProtKB:A0A8M9Q1Z3
|
439 |
Interactions and Pathways
No data available
Plasmids
No data available