Gene
eps8l3a
- ID
- ZDB-GENE-091204-460
- Name
- EPS8 signaling adaptor L3a
- Symbol
- eps8l3a Nomenclature History
- Previous Names
-
- si:ch211-103a14.4
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to contribute to Rac guanyl-nucleotide exchange factor activity. Predicted to be involved in Rho protein signal transduction; positive regulation of ruffle assembly; and regulation of Rho protein signal transduction. Predicted to localize to ruffle membrane. Human ortholog(s) of this gene implicated in hypotrichosis 5. Orthologous to human EPS8L3 (EPS8 like 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypotrichosis 5 | Alliance | ?Hypotrichosis 5 | 612841 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001452 | SH3 domain |
| Domain | IPR013625 | Tensin/EPS8 phosphotyrosine-binding domain |
| Domain | IPR033928 | Epidermal growth factor receptor kinase substrate, phosphotyrosine-binding domain |
| Domain | IPR035462 | Eps8, SH3 domain |
| Domain | IPR041418 | SAM domain |
| Family | IPR039801 | Epidermal growth factor receptor kinase substrate 8-like |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Epidermal growth factor receptor kinase substrate 8-like | Epidermal growth factor receptor kinase substrate, phosphotyrosine-binding domain | Eps8, SH3 domain | PH-like domain superfamily | SAM domain | SH3 domain | SH3-like domain superfamily | Sterile alpha motif/pointed domain superfamily | Tensin/EPS8 phosphotyrosine-binding domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7F362
|
646 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
eps8l3a-201
(1)
|
Havana | 2383 nt |
Interactions and Pathways
No data available
Plasmids
No data available