Gene
htr3a
- ID
- ZDB-GENE-071012-5
- Name
- 5-hydroxytryptamine (serotonin) receptor 3A
- Symbol
- htr3a Nomenclature History
- Previous Names
-
- si:dkeyp-14b8.5
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have extracellular ligand-gated ion channel activity and transmembrane signaling receptor activity. Predicted to be involved in several processes, including chemical synaptic transmission; nervous system process; and regulation of membrane potential. Predicted to localize to integral component of plasma membrane; neuron projection; and synapse. Human ortholog(s) of this gene implicated in irritable bowel syndrome. Orthologous to human HTR3A (5-hydroxytryptamine receptor 3A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018000 | Neurotransmitter-gated ion-channel, conserved site |
| Domain | IPR006029 | Neurotransmitter-gated ion-channel transmembrane domain |
| Domain | IPR006202 | Neurotransmitter-gated ion-channel ligand-binding domain |
| Domain | IPR049944 | 5-hydroxytryptamine 3 receptor, transmembrane domain |
| Family | IPR006201 | Neurotransmitter-gated ion-channel |
| Family | IPR008132 | 5-hydroxytryptamine 3 receptor |
| Family | IPR008133 | 5-hydroxytryptamine 3 receptor, A subunit |
| Homologous_superfamily | IPR036719 | Neurotransmitter-gated ion-channel transmembrane domain superfamily |
| Homologous_superfamily | IPR036734 | Neurotransmitter-gated ion-channel ligand-binding domain superfamily |
| Homologous_superfamily | IPR038050 | Neuronal acetylcholine receptor |
Domain Details Per Protein
| Protein | Length | 5-hydroxytryptamine 3 receptor | 5-hydroxytryptamine 3 receptor, A subunit | 5-hydroxytryptamine 3 receptor, transmembrane domain | Neuronal acetylcholine receptor | Neurotransmitter-gated ion-channel | Neurotransmitter-gated ion-channel, conserved site | Neurotransmitter-gated ion-channel ligand-binding domain | Neurotransmitter-gated ion-channel ligand-binding domain superfamily | Neurotransmitter-gated ion-channel transmembrane domain | Neurotransmitter-gated ion-channel transmembrane domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PD95
|
388 | ||||||||||
|
UniProtKB:A0A8M3AM85
|
482 |
Interactions and Pathways
No data available
Plasmids
No data available