Gene
pde8b
- ID
- ZDB-GENE-091117-3
- Name
- phosphodiesterase 8B
- Symbol
- pde8b Nomenclature History
- Previous Names
-
- si:dkeyp-1d11.1
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in negative regulation of cAMP/PKA signal transduction and positive regulation of ERK1 and ERK2 cascade. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease 3. Orthologous to human PDE8B (phosphodiesterase 8B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary pigmented nodular adrenocortical disease 3 | Alliance | Pigmented nodular adrenocortical disease, primary, 3 | 614190 |
| striatonigral degeneration | Alliance | Striatal degeneration, autosomal dominant | 609161 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023174 | 3'5'-cyclic nucleotide phosphodiesterase, conserved site |
| Domain | IPR000014 | PAS domain |
| Domain | IPR002073 | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain |
| Domain | IPR003607 | HD/PDEase domain |
| Domain | IPR013767 | PAS fold |
| Domain | IPR013938 | 3'5'-cyclic nucleotide phosphodiesterase PDE8 |
| Family | IPR023088 | 3'5'-cyclic nucleotide phosphodiesterase |
| Homologous_superfamily | IPR035965 | PAS domain superfamily |
| Homologous_superfamily | IPR036971 | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | 3'5'-cyclic nucleotide phosphodiesterase | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | 3'5'-cyclic nucleotide phosphodiesterase PDE8 | HD/PDEase domain | PAS domain | PAS domain superfamily | PAS fold |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AWN1 | InterPro | 874 | |||||||||
| UniProtKB:A0A8M9P3K9 | InterPro | 797 | |||||||||
| UniProtKB:A0A8M3ATN7 | InterPro | 788 |
Interactions and Pathways
No data available
Plasmids
No data available