Gene
duox
- ID
- ZDB-GENE-091117-14
- Name
- dual oxidase
- Symbol
- duox Nomenclature History
- Previous Names
-
- duox1
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have superoxide-generating NADPH oxidase activity. Involved in several processes, including hydrogen peroxide biosynthetic process; leukocyte migration; and thyroid gland development. Predicted to localize to NADPH oxidase complex. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in congenital hypothyroidism. Is expressed in several structures, including central nervous system; endocrine system; epidermis; intestine; and swim bladder. Orthologous to human DUOX1 (dual oxidase 1) and DUOX2 (dual oxidase 2).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 15 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
thyroid dyshormonogenesis 6 | Alliance | Thyroid dyshormonogenesis 6 | 607200 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
Protein | Length |
---|---|
UniProtKB:A0A8M6YYK2
|
1528 |
UniProtKB:A0A8M9PVM3
|
1528 |
UniProtKB:A0A8M9P6X2
|
1527 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available