Gene
tgfb1b
- ID
- ZDB-GENE-091028-1
- Name
- transforming growth factor, beta 1b
- Symbol
- tgfb1b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Acts upstream of or within with a positive effect on JNK cascade. Acts upstream of or within hematopoietic stem cell differentiation. Predicted to be active in extracellular space. Is expressed in cardiovascular system; head; hematopoietic system; male organism; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; artery disease (multiple); bone disease (multiple); carcinoma (multiple); and lung disease (multiple). Orthologous to human TGFB1 (transforming growth factor beta 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Zhang et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Camurati-Engelmann disease | Alliance | Camurati-Engelmann disease | 131300 |
| cystic fibrosis | Alliance | {Cystic fibrosis lung disease, modifier of} | 219700 |
| Inflammatory bowel disease, immunodeficiency, and encephalopathy | 618213 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017948 | Transforming growth factor beta, conserved site |
| Domain | IPR001111 | TGF-beta, propeptide |
| Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
| Family | IPR015615 | Transforming growth factor-beta-related |
| Family | IPR016319 | Transforming growth factor-beta |
| Homologous_superfamily | IPR029034 | Cystine-knot cytokine |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | TGF-beta, propeptide | Transforming growth factor-beta | Transforming growth factor beta, conserved site | Transforming growth factor-beta, C-terminal | Transforming growth factor-beta-related |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:E9QHW0 | InterPro | 379 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tgfb1b-201
(1)
|
Ensembl | 1,403 nt |
Interactions and Pathways
No data available
Plasmids
No data available