ZFIN is now using GRCz12tu for Genomic Data
Gene
erlin2
- ID
- ZDB-GENE-090505-4
- Name
- ER lipid raft associated 2
- Symbol
- erlin2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in ERAD pathway and SREBP signaling pathway. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 18A and hereditary spastic paraplegia 18B. Orthologous to human ERLIN2 (ER lipid raft associated 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6907527 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary spastic paraplegia 18A | Alliance | Spastic paraplegia 18A, autosomal dominant | 620512 |
| hereditary spastic paraplegia 18B | Alliance | Spastic paraplegia 18B, autosomal recessive | 611225 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Band 7 domain | Erlin1/2 |
|---|---|---|---|---|
| UniProtKB:A3QK16 | InterPro | 331 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ch25hl3-201
(1)
|
Ensembl | 3,869 nt | ||
| mRNA |
erlin2-201
(1)
|
Ensembl | 774 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers