Gene

rasa3

ID

ZDB-GENE-090313-21

Name

RAS p21 protein activator 3

Symbol

rasa3 Nomenclature History

Previous Names

si:ch211-129c2.7

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have GTPase activator activity and metal ion binding activity. Involved in blood vessel lumenization; nucleate erythrocyte differentiation; and thrombocyte differentiation. Is expressed in central nervous system. Orthologous to human RASA3 (RAS p21 protein activator 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Blanc et al., 2012

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rasa3 Human Ortholog

No data available

Associated With rasa3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001562	Zinc finger, Btk motif
Conserved_site	IPR023152	Ras GTPase-activating protein, conserved site
Domain	IPR000008	C2 domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR001936	Ras GTPase-activating domain
Domain	IPR037774	RASA3, PH domain
Family	IPR039360	Ras GTPase-activating protein
Homologous_superfamily	IPR008936	Rho GTPase activation protein
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035892	C2 domain superfamily

Domain Details Per Protein

Protein	Length	C2 domain	C2 domain superfamily	PH-like domain superfamily	Pleckstrin homology domain	RASA3, PH domain	Ras GTPase-activating domain	Ras GTPase-activating protein	Ras GTPase-activating protein, conserved site	Rho GTPase activation protein	Zinc finger, Btk motif
UniProtKB:A0A8M3B360 InterPro	853
UniProtKB:E7F916 InterPro	833
UniProtKB:A0A8M3AWN9 InterPro	849
UniProtKB:A0A8M3AWL8 InterPro	837

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	rasa3-201 (1) Ensembl	Ensembl		2,894 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations