Gene
socs1b
- ID
- ZDB-GENE-090313-141
- Name
- suppressor of cytokine signaling 1b
- Symbol
- socs1b Nomenclature History
- Previous Names
-
- si:ch73-191k20.2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable cytokine receptor binding activity. Predicted to be involved in cytokine-mediated signaling pathway and negative regulation of receptor signaling pathway via JAK-STAT. Predicted to act upstream of or within intracellular signal transduction and negative regulation of signal transduction. Is expressed in head kidney. Human ortholog(s) of this gene implicated in acute myeloid leukemia; gastrointestinal system cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human SOCS1 (suppressor of cytokine signaling 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from López-Muñoz et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Lawir et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Autoinflammatory syndrome, familial, with or without immunodeficiency | 619375 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | SH2 domain | SH2 domain superfamily | SOCS1, SH2 domain | SOCS box domain | SOCS box-like domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:E7FDH8
|
193 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
socs1b-201
(1)
|
Ensembl | 964 nt | ||
| mRNA |
socs1b-202
(1)
|
Ensembl | 632 nt |
Interactions and Pathways
No data available
Plasmids
No data available