Gene

kcnma1a

ID

ZDB-GENE-070202-9

Name

potassium large conductance calcium-activated channel, subfamily M, alpha member 1a

Symbol

kcnma1a Nomenclature History

Previous Names

kcnma1
slo1a (1)
si:ch211-39f22.2

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Enables calcium ion binding activity and calcium-activated potassium channel activity. Involved in potassium ion transmembrane transport. Acts upstream of or within response to auditory stimulus. Located in membrane. Is expressed in several structures, including brain; otic vesicle; pectoral fin bud; peripheral olfactory organ; and presumptive diencephalon. Human ortholog(s) of this gene implicated in Alzheimer's disease; idiopathic generalized epilepsy; and paroxysmal nonkinesigenic dyskinesia 3. Orthologous to human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Rohmann et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kcnma1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
paroxysmal nonkinesigenic dyskinesia 3	Alliance	Paroxysmal nonkinesigenic dyskinesia, 3, with or without generalized epilepsy	609446
		Cerebellar atrophy, developmental delay, and seizures	617643
		Liang-Wang syndrome	618729
		{Epilepsy, idiopathic generalized, susceptibility to, 16}	618596

Associated With kcnma1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003929	Calcium-activated potassium channel BK, alpha subunit
Domain	IPR005821	Ion transport domain
Domain	IPR048735	Ca2+-activated K+ channel Slowpoke-like, C-terminal domain
Domain	IPR055153	Calcium-activated potassium channel slowpoke-like, RCK domain
Family	IPR047871	Calcium-activated potassium channel slowpoke-like
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily

Domain Details Per Protein

Protein	Length	Ca2+-activated K+ channel Slowpoke-like, C-terminal domain	Calcium-activated potassium channel BK, alpha subunit	Calcium-activated potassium channel slowpoke-like	Calcium-activated potassium channel slowpoke-like, RCK domain	Ion transport domain	NAD(P)-binding domain superfamily
UniProtKB:B7ZC96 InterPro PDB	1184
UniProtKB:F1QYL4 InterPro	1229
UniProtKB:A0A8M6Z3V4 InterPro	1151
UniProtKB:A0A8M3B7Y4 InterPro	1302
UniProtKB:A0A8M2B2Q5 InterPro	1233
UniProtKB:A0A8M3AYZ7 InterPro	1305
UniProtKB:A0A8M2B303 InterPro	1204
UniProtKB:A0A8M3B7Y9 InterPro	1252
UniProtKB:A0A8M9QNH1 InterPro	1244
UniProtKB:A0A8M6Z9M0 InterPro	1148
UniProtKB:A0A2R8QRZ7 InterPro	1229
UniProtKB:A0A8M2B3F4 InterPro	1208
UniProtKB:A0A8M9PY23 InterPro	1148
UniProtKB:A0A8M6Z2C3 InterPro	1152
UniProtKB:A0A8M3B560 InterPro	1301
UniProtKB:A0A8M3BEL0 InterPro	1263
UniProtKB:A0A8M6Z968 InterPro	1179
UniProtKB:A0A8M9QJS7 InterPro	1201
UniProtKB:A0A8M9PY17 InterPro	1208
UniProtKB:A0A8M6Z9L7 InterPro	1224
UniProtKB:A0A8M3AZ19 InterPro	1277
UniProtKB:A0A8M2B3K4 InterPro	1210
UniProtKB:A0A8M6Z1R0 InterPro	1180
UniProtKB:A0A8M9QNH5 InterPro	1204
UniProtKB:A0A8M3AZ02 InterPro	1252
UniProtKB:A0A8M2B2T1 InterPro	1232
UniProtKB:A0A8M9Q9V0 InterPro	1305
UniProtKB:A0A8M9QFI9 InterPro	672
UniProtKB:A0A8M3AZ25 InterPro	956
UniProtKB:A0A8M2B2Q8 InterPro	1206
UniProtKB:A0A8M3B563 InterPro	1213
UniProtKB:A0A8M2B2Z4 InterPro	1266
UniProtKB:A0A8M2B2S7 InterPro	1294
UniProtKB:A0A8M9QFI6 InterPro	1205
UniProtKB:A0A8M2B3E8 InterPro	1236
UniProtKB:A0A8M2B3J8 InterPro	1259

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	kcnma1a-201 (1) Ensembl	Ensembl	4,328 nt	Select Tool ZFIN BLAST
mRNA	kcnma1a-205 (1) Ensembl	Ensembl	3,823 nt	Select Tool ZFIN BLAST
mRNA	kcnma1a-206 (1) Ensembl	Ensembl	3,690 nt	Select Tool ZFIN BLAST
ncRNA	kcnma1a-002 (1) Ensembl	Ensembl	849 nt	Select Tool ZFIN BLAST
ncRNA	kcnma1a-003 (1) Ensembl	Ensembl	725 nt	Select Tool ZFIN BLAST
ncRNA	kcnma1a-004 (1) Ensembl	Ensembl	857 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations