Gene

tet2

ID

ZDB-GENE-090312-98

Name

tet methylcytosine dioxygenase 2

Symbol

tet2 Nomenclature History

Previous Names

tet2l (1)
im:7136741
si:ch211-216c6.1

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Enables methylcytosine dioxygenase activity. Involved in regulation of gene expression. Acts upstream of or within several processes, including cell surface receptor signaling pathway; endothelial to hematopoietic transition; and hemopoiesis. Predicted to be active in nucleus. Is expressed in several structures, including cardiovascular system; eye; hematopoietic system; liver; and pleuroperitoneal region. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to human TET2 (tet methylcytosine dioxygenase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 11 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7136741 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 13 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tet2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
myelodysplastic syndrome	Alliance	Myelodysplastic syndrome, somatic	614286
		Immunodeficiency 75	619126

Associated With tet2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
myelodysplastic syndrome	tet2^zdf20/zdf20	standard conditions	Gjini et al., 2015

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR024779	2OGFeDO JBP1/TET, oxygenase domain
Domain	IPR046942	Methylcytosine dioxygenase TET1-3, oxygenase domain
Family	IPR040175	Methylcytosine dioxygenase TET1/2/3

Domain Details Per Protein

Protein	Length	2OGFeDO JBP1/TET, oxygenase domain	Methylcytosine dioxygenase TET1/2/3	Methylcytosine dioxygenase TET1-3, oxygenase domain
UniProtKB:E7F958 InterPro	1715

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tet2-201 (1) Ensembl	Ensembl	8,807 nt	Select Tool ZFIN BLAST
mRNA	tet2-202 (1) Ensembl	Ensembl	5,887 nt	Select Tool ZFIN BLAST
mRNA	tet2-203 (1) Ensembl	Ensembl	6,319 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations