Gene
sos2
- ID
- ZDB-GENE-090319-5
- Name
- son of sevenless homolog 2 (Drosophila)
- Symbol
- sos2 Nomenclature History
- Previous Names
-
- si:ch211-67f24.8
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have DNA binding activity; guanyl-nucleotide exchange factor activity; and protein heterodimerization activity. Involved in pronephros development. Predicted to localize to nucleosome. Human ortholog(s) of this gene implicated in Noonan syndrome 9. Orthologous to human SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Li et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Li et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Noonan syndrome 9 | Alliance | Noonan syndrome 9 | 616559 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019804 | Ras guanine-nucleotide exchange factor, conserved site |
| Domain | IPR000219 | Dbl homology (DH) domain |
| Domain | IPR000651 | Ras-like guanine nucleotide exchange factor, N-terminal |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR001895 | Ras guanine-nucleotide exchange factors catalytic domain |
| Family | IPR008937 | Ras-like guanine nucleotide exchange factor |
| Homologous_superfamily | IPR009072 | Histone-fold |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR023578 | Ras guanine nucleotide exchange factor domain superfamily |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
| Homologous_superfamily | IPR036964 | Ras guanine-nucleotide exchange factor, catalytic domain superfamily |
Domain Details Per Protein
| Protein | Length | Dbl homology (DH) domain | Dbl homology (DH) domain superfamily | Histone-fold | PH-like domain superfamily | Pleckstrin homology domain | Ras guanine-nucleotide exchange factor, catalytic domain superfamily | Ras guanine-nucleotide exchange factor, conserved site | Ras guanine nucleotide exchange factor domain superfamily | Ras guanine-nucleotide exchange factors catalytic domain | Ras-like guanine nucleotide exchange factor | Ras-like guanine nucleotide exchange factor, N-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1R019
|
1341 |
Interactions and Pathways
No data available
Plasmids
No data available