Gene
rasa1b
- ID
- ZDB-GENE-090311-50
- Name
- RAS p21 protein activator (GTPase activating protein) 1b
- Symbol
- rasa1b Nomenclature History
- Previous Names
-
- si:dkey-169a9.2
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have GTPase activator activity. Predicted to be involved in negative regulation of Ras protein signal transduction; positive regulation of GTPase activity; and signal transduction. Human ortholog(s) of this gene implicated in arteriovenous malformation and basal cell carcinoma. Is expressed in head. Orthologous to human RASA1 (RAS p21 protein activator 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Kawasaki et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023152 | Ras GTPase-activating protein, conserved site |
| Domain | IPR000008 | C2 domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR001936 | Ras GTPase-activating domain |
| Domain | IPR035652 | RasGAP, SH3 domain |
| Domain | IPR035842 | Ras GTPase-activating protein 1, C-terminal SH2 domain |
| Family | IPR039360 | Ras GTPase-activating protein |
| Homologous_superfamily | IPR008936 | Rho GTPase activation protein |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | C2 domain | C2 domain superfamily | PH-like domain superfamily | Pleckstrin homology domain | RasGAP, SH3 domain | Ras GTPase-activating domain | Ras GTPase-activating protein | Ras GTPase-activating protein 1, C-terminal SH2 domain | Ras GTPase-activating protein, conserved site | Rho GTPase activation protein | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7F372
|
1032 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
rasa1b-201
(1)
|
Havana | 4941 nt | |
| ncRNA |
rasa1b-002
(1)
|
Havana | 717 nt |
Interactions and Pathways
No data available
Plasmids