Gene

crhr1

ID

ZDB-GENE-081231-1

Name

corticotropin releasing hormone receptor 1

Symbol

crhr1 Nomenclature History

Previous Names

crfr1 (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have corticotrophin-releasing factor receptor activity; corticotropin-releasing hormone receptor activity; and peptide hormone binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and obesity. Is expressed in griseum centrale and hindbrain. Orthologous to several human genes including LINC02210-CRHR1 (LINC02210-CRHR1 readthrough).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Faught et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With crhr1 Human Ortholog

No data available

Associated With crhr1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017983	GPCR, family 2, secretin-like, conserved site
Domain	IPR001879	GPCR, family 2, extracellular hormone receptor domain
Domain	IPR017981	GPCR, family 2-like, 7TM
Family	IPR000832	GPCR, family 2, secretin-like
Family	IPR003051	GPCR, family 2, corticotropin releasing factor receptor
Family	IPR003052	GPCR, family 2, corticotropin releasing factor receptor, type 1
Homologous_superfamily	IPR036445	GPCR family 2, extracellular hormone receptor domain superfamily