Gene

prop1

ID

ZDB-GENE-081107-40

Name

PROP paired-like homeobox 1

Symbol

prop1 Nomenclature History

Previous Names

si:ch211-93n23.5 (1)

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within adenohypophysis development. Predicted to be located in nucleus. Is expressed in hypophysis. Human ortholog(s) of this gene implicated in combined pituitary hormone deficiency 2; hypogonadism; and hypopituitarism. Orthologous to human PROP1 (PROP paired-like homeobox 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Angotzi et al., 2011

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Angotzi et al., 2011
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prop1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
combined pituitary hormone deficiency 2	Alliance	Pituitary hormone deficiency, combined, 2	262600

Associated With prop1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Family	IPR042412	Homeobox protein prophet of Pit-1
Homologous_superfamily	IPR009057	Homedomain-like superfamily