Gene
dlk2
- ID
- ZDB-GENE-081107-4
- Name
- delta-like 2 homolog (Drosophila)
- Symbol
- dlk2 Nomenclature History
- Previous Names
-
- si:ch211-117c8.3
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable Notch binding activity. Acts upstream of or within negative regulation of Notch signaling pathway; negative regulation of angiogenesis; and vasculature development. Predicted to be located in membrane. Orthologous to human DLK2 (delta like non-canonical Notch ligand 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Rodríguez et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Family | IPR050906 | Notch signaling pathway |
| Family | IPR051022 | Notch Signaling and Cell Fate Determination |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Notch Signaling and Cell Fate Determination | Notch signaling pathway |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B7S7 | InterPro | 373 | |||||||
| UniProtKB:A0A8M9PYA6 | InterPro | 378 | |||||||
| UniProtKB:A0A8M3B4Z9 | InterPro | 372 |
Interactions and Pathways
No data available
Plasmids
No data available