Gene

rapgef1a

ID

ZDB-GENE-081105-26

Name

Rap guanine nucleotide exchange factor (GEF) 1a

Symbol

rapgef1a Nomenclature History

Previous Names

si:ch211-127h20.2

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have guanyl-nucleotide exchange factor activity. Predicted to be involved in small GTPase mediated signal transduction. Orthologous to human RAPGEF1 (Rap guanine nucleotide exchange factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Li et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rapgef1a Human Ortholog

No data available

Associated With rapgef1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019804	Ras guanine-nucleotide exchange factor, conserved site
Domain	IPR000651	Ras-like guanine nucleotide exchange factor, N-terminal
Domain	IPR001895	Ras guanine-nucleotide exchange factors catalytic domain
Family	IPR008937	Ras-like guanine nucleotide exchange factor
Homologous_superfamily	IPR023578	Ras guanine nucleotide exchange factor domain superfamily
Homologous_superfamily	IPR036964	Ras guanine-nucleotide exchange factor, catalytic domain superfamily

Domain Details Per Protein

Protein	Length	Ras guanine-nucleotide exchange factor, catalytic domain superfamily	Ras guanine-nucleotide exchange factor, conserved site	Ras guanine nucleotide exchange factor domain superfamily	Ras guanine-nucleotide exchange factors catalytic domain	Ras-like guanine nucleotide exchange factor	Ras-like guanine nucleotide exchange factor, N-terminal
UniProtKB:A0A8M3AUZ3 InterPro	999
UniProtKB:A0A8M2BED2 InterPro	1085
UniProtKB:A0A8M3B1T6 InterPro	1030
UniProtKB:A0A8M3B4Q5 InterPro	1054

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rapgef1a-201 (1) Ensembl	Ensembl	3,081 nt	Select Tool ZFIN BLAST
mRNA	rapgef1a-202 (1) Ensembl	Ensembl	3,399 nt	Select Tool ZFIN BLAST
mRNA	rapgef1a-203 (1) Ensembl	Ensembl	2,907 nt	Select Tool ZFIN BLAST
mRNA	rapgef1a-204 (1) Ensembl	Ensembl	2,817 nt	Select Tool ZFIN BLAST
mRNA	rapgef1a-205 (1) Ensembl	Ensembl	3,039 nt	Select Tool ZFIN BLAST
mRNA	rapgef1a-206 (1) Ensembl	Ensembl	2,919 nt	Select Tool ZFIN BLAST
mRNA	rapgef1a-207 (1) Ensembl	Ensembl	2,910 nt	Select Tool ZFIN BLAST
mRNA	rapgef1a-208 (1) Ensembl	Ensembl	2,907 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations