Gene
six2b
- ID
- ZDB-GENE-080723-23
- Name
- SIX homeobox 2b
- Symbol
- six2b Nomenclature History
- Previous Names
-
- zgc:195089
- zgc:195096
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within pronephros morphogenesis. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in intermediate mesoderm; otic vesicle; and pronephric tubule. Human ortholog(s) of this gene implicated in renal Wilms' tumor. Orthologous to human SIX2 (SIX homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Belcher et al., 2023
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Belcher et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein SIX1, N-terminal SD domain | Homeodomain | KN homeodomain |
|---|---|---|---|---|---|---|
|
UniProtKB:B3DIJ7
|
285 |
Interactions and Pathways
No data available
Plasmids
No data available