Gene
megf10
- ID
- ZDB-GENE-080506-1
- Name
- multiple EGF-like-domains 10
- Symbol
- megf10 Nomenclature History
- Previous Names
-
- fc33e05
- wu:fc33e05 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable scavenger receptor activity. Involved in positive regulation of muscle tissue development. Acts upstream of or within myofibril assembly. Predicted to be located in plasma membrane. Used to study myopathy. Human ortholog(s) of this gene implicated in congenital myopathy 10B and early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome. Orthologous to human MEGF10 (multiple EGF like domains 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital myopathy 10B | Alliance | Congenital myopathy 10B, mild variant | 620249 |
| early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome | Alliance | Congenital myopathy 10A, severe variant | 614399 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| myopathy | megf10sa13029/sa13029 | standard conditions | Saha et al., 2019 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | EGF-like, conserved site | EGF-like domain | EMI domain | Laminin-type EGF domain | MEGF10/SREC1/2-like |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1QV85
|
1120 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
megf10-201
(1)
|
Ensembl | 3,544 nt | ||
| mRNA |
megf10-203
(1)
|
Ensembl | 3,225 nt | ||
| mRNA |
megf10-204
(1)
|
Ensembl | 3,429 nt | ||
| ncRNA |
megf10-002
(1)
|
Ensembl | 797 nt |
Interactions and Pathways
No data available
Plasmids
No data available