Gene
pgr
- ID
- ZDB-GENE-990415-214
- Name
- progesterone receptor
- Symbol
- pgr Nomenclature History
- Previous Names
-
- gb:dq017620
- NR3C3 (1)
- pr
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Exhibits steroid binding activity and steroid hormone receptor activity. Involved in luteinizing hormone signaling pathway and ovulation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in endometriosis; hyperprolactinemia; and obesity. Is expressed in several structures, including brain; digestive system; gonad; steroid hormone secreting cell; and ventricular zone. Orthologous to human PGR (progesterone receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 32 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017620 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Progesterone resistance | 264080 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|
|
UniProtKB:C9V3N7
|
617 |
Interactions and Pathways
Plasmids
No data available