Gene
dmgdh
- ID
- ZDB-GENE-080227-8
- Name
- dimethylglycine dehydrogenase
- Symbol
- dmgdh Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable dimethylglycine dehydrogenase activity. Predicted to be involved in choline metabolic process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in dimethylglycine dehydrogenase deficiency. Orthologous to human DMGDH (dimethylglycine dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dimethylglycine dehydrogenase deficiency | Alliance | Dimethylglycine dehydrogenase deficiency | 605850 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006076 | FAD dependent oxidoreductase |
| Domain | IPR006222 | Aminomethyltransferase, folate-binding domain |
| Domain | IPR013977 | Aminomethyltransferase, C-terminal domain |
| Domain | IPR032503 | FAD dependent oxidoreductase, central domain |
| Family | IPR028896 | Aminomethyltransferase-like |
| Homologous_superfamily | IPR027266 | GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 |
| Homologous_superfamily | IPR029043 | Glycine cleavage T-protein/YgfZ, C-terminal |
| Homologous_superfamily | IPR036188 | FAD/NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Aminomethyltransferase, C-terminal domain | Aminomethyltransferase, folate-binding domain | Aminomethyltransferase-like | FAD dependent oxidoreductase | FAD dependent oxidoreductase, central domain | FAD/NAD(P)-binding domain superfamily | Glycine cleavage T-protein/YgfZ, C-terminal | GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB32TAW6 | InterPro | 900 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available