Gene
prkg1b
- ID
- ZDB-GENE-080225-40
- Name
- protein kinase cGMP-dependent 1b
- Symbol
- prkg1b Nomenclature History
- Previous Names
-
- im:7159478
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable cAMP-dependent protein kinase regulator activity; cGMP-dependent protein kinase activity; and purine ribonucleotide binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within protein phosphorylation and regulation of protein phosphorylation. Predicted to be part of cAMP-dependent protein kinase complex. Is expressed in several structures, including female organism; heart; integument; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human PRKG1 (protein kinase cGMP-dependent 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7159478 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| thoracic aortic aneurysm | Alliance | Aortic aneurysm, familial thoracic 8 | 615436 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR018488 | Cyclic nucleotide-binding, conserved site |
| Domain | IPR000595 | Cyclic nucleotide-binding domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR031831 | cGMP-dependent protein kinase, N-terminal coiled-coil domain |
| Domain | IPR035014 | cGMP-dependent protein kinase, catalytic domain |
| Family | IPR002374 | cGMP-dependent kinase |
| Family | IPR012198 | cAMP-dependent protein kinase regulatory subunit |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR014710 | RmlC-like jelly roll fold |
| Homologous_superfamily | IPR018490 | Cyclic nucleotide-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | AGC-kinase, C-terminal | cAMP-dependent protein kinase regulatory subunit | cGMP-dependent kinase | cGMP-dependent protein kinase, catalytic domain | cGMP-dependent protein kinase, N-terminal coiled-coil domain | Cyclic nucleotide-binding, conserved site | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | RmlC-like jelly roll fold | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9Q0L9
|
378 | |||||||||||||
|
UniProtKB:A0A8M9QIZ6
|
342 | |||||||||||||
|
UniProtKB:A0A2R8Q8R8
|
684 | |||||||||||||
|
UniProtKB:F1R125
|
669 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prkg1b-201
(1)
|
Ensembl | 2,010 nt | ||
| mRNA |
prkg1b-203
(1)
|
Ensembl | 2,072 nt | ||
| mRNA |
prkg1b-204
(1)
|
Ensembl | 2,055 nt | ||
| mRNA |
prkg1b-205
(1)
|
Ensembl | 1,923 nt | ||
| ncRNA |
prkg1b-002
(1)
|
Ensembl | 942 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance