Gene
tbx21
- ID
- ZDB-GENE-080104-3
- Name
- T-box transcription factor 21
- Symbol
- tbx21 Nomenclature History
- Previous Names
-
- T-bet (2)
- tbx21l
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including heart looping; lymphocyte migration; and regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance. Is expressed in several structures, including digestive system; hematopoietic system; integument; kidney; and telencephalon. Orthologous to human TBX21 (T-box transcription factor 21).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| asthma, nasal polyps, and aspirin intolerance | Alliance | Asthma and nasal polyps | 208550 |
| asthma, nasal polyps, and aspirin intolerance | Alliance | {Asthma, aspirin-induced, susceptibility to} | 208550 |
| ?Immunodeficiency 88 | 619630 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018186 | Transcription factor, T-box, conserved site |
| Domain | IPR032385 | T-box transcription factor-associated |
| Domain | IPR046360 | T-box transcription factor, DNA-binding domain |
| Family | IPR001699 | T-box transcription factor |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR036960 | T-box superfamily |
Domain Details Per Protein
| Protein | Length | p53-like transcription factor, DNA-binding domain superfamily | T-box superfamily | T-box transcription factor | T-box transcription factor-associated | T-box transcription factor, DNA-binding domain | Transcription factor, T-box, conserved site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:D1YT98
|
609 |
Interactions and Pathways
No data available
Plasmids
No data available