Gene
dync2i2
- ID
- ZDB-GENE-070928-9
- Name
- dynein 2 intermediate chain 2
- Symbol
- dync2i2 Nomenclature History
- Previous Names
-
- dync2i1
- wdr34
- zgc:171284 (1)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to contribute to ATP-dependent microtubule motor activity, plus-end-directed. Involved in intraciliary transport. Predicted to localize to ciliary plasm and cytoplasmic dynein complex. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 11 with or without polydactyly. Is expressed in central nervous system; pronephric duct; and retina. Orthologous to human WDR34 (WD repeat domain 34).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Krock et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| short-rib thoracic dysplasia 11 with or without polydactyly | Alliance | Short-rib thoracic dysplasia 11 with or without polydactyly | 615633 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| neural tube defect | AB + MO1-dync2i2 | standard conditions | Yin et al., 2020 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|
|
UniProtKB:A7MD87
|
501 |
Interactions and Pathways
No data available
Plasmids
No data available