Gene

arhgef4

ID

ZDB-GENE-070912-575

Name

Rho guanine nucleotide exchange factor (GEF) 4

Symbol

arhgef4 Nomenclature History

Previous Names

si:dkey-74f15.3

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have guanyl-nucleotide exchange factor activity. Predicted to be involved in intracellular signal transduction. Predicted to localize to integral component of membrane. Orthologous to human ARHGEF4 (Rho guanine nucleotide exchange factor 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Olson et al., 2024

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arhgef4 Human Ortholog

No data available

Associated With arhgef4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR001452	SH3 domain
Domain	IPR001849	Pleckstrin homology domain
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily

Domain Details Per Protein

Protein	Length	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	PH-like domain superfamily	Pleckstrin homology domain	SH3 domain	SH3-like domain superfamily
UniProtKB:A0A8M3B7L7 InterPro	3031
UniProtKB:A0A8M3B060 InterPro	2988
UniProtKB:A0A8N7USX6 InterPro	646
UniProtKB:A0A8M9PKC3 InterPro	3070
UniProtKB:E7FAH9 InterPro	3063
UniProtKB:A0A8M9PDX0 InterPro	3070
UniProtKB:A0A8M3AQ48 InterPro	3031
UniProtKB:A0A8M3B055 InterPro	3088

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	arhgef4-201 (1) Ensembl	Ensembl	10,438 nt	Select Tool
mRNA	arhgef4-202 (1) Ensembl	Ensembl	2,917 nt	Select Tool
mRNA	arhgef4-203 (1) Ensembl	Ensembl	3,431 nt	Select Tool
mRNA	arhgef4-204 (1) Ensembl	Ensembl	1,722 nt	Select Tool ZFIN BLAST
mRNA	arhgef4-205 (1) Ensembl	Ensembl	162 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations