Gene
gad1a
- ID
- ZDB-GENE-070912-472
- Name
- glutamate decarboxylase 1a
- Symbol
- gad1a Nomenclature History
- Previous Names
-
- si:dkey-249g23.3
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to have carboxy-lyase activity and pyridoxal phosphate binding activity. Predicted to be involved in carboxylic acid metabolic process. Human ortholog(s) of this gene implicated in anxiety disorder; bipolar disorder; schizophrenia; and spastic quadriplegia. Is expressed in brain. Orthologous to human GAD1 (glutamate decarboxylase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 89 | Alliance | Developmental and epileptic encephalopathy 89 | 619124 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR021115 | Pyridoxal-phosphate binding site |
| Family | IPR002129 | Pyridoxal phosphate-dependent decarboxylase |
| Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
| Homologous_superfamily | IPR015424 | Pyridoxal phosphate-dependent transferase |
Domain Details Per Protein
| Protein | Length | Pyridoxal-phosphate binding site | Pyridoxal phosphate-dependent decarboxylase | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QB27
|
571 | ||||
|
UniProtKB:A0A8M9QJY1
|
548 | ||||
|
UniProtKB:A0A8M1RDR2
|
591 |
Interactions and Pathways
No data available
Plasmids
No data available