Gene
dgkh
- ID
- ZDB-GENE-070912-328
- Name
- diacylglycerol kinase, eta
- Symbol
- dgkh Nomenclature History
- Previous Names
-
- si:ch211-93a19.1
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable ATP-dependent diacylglycerol kinase activity. Predicted to be involved in diacylglycerol metabolic process; intracellular signal transduction; and phosphatidic acid biosynthetic process. Predicted to act upstream of or within lipid metabolic process; phosphorylation; and signal transduction. Predicted to be active in plasma membrane. Is expressed in Purkinje cell. Orthologous to human DGKH (diacylglycerol kinase eta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Takeuchi et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa8698 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10472 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11568 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34602 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34603 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34604 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41389 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000756 | Diacylglycerol kinase, accessory domain |
| Domain | IPR001206 | Diacylglycerol kinase, catalytic domain |
| Domain | IPR001660 | Sterile alpha motif domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | C1-like domain superfamily | Diacylglycerol kinase | Diacylglycerol kinase, accessory domain | Diacylglycerol kinase, catalytic domain | Diacylglycerol kinase eta/delta/kappa, helical domain | Diacylglycerol kinase eta, second protein kinase C conserved region 1 | Inorganic polyphosphate/ATP-NAD kinase, N-terminal | NAD kinase/diacylglycerol kinase-like domain superfamily | PH-like domain superfamily | Pleckstrin homology domain | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PSF8 | InterPro | 197 | |||||||||||||
| UniProtKB:A0A8M2BFF5 | InterPro | 1257 | |||||||||||||
| UniProtKB:A0A8M9PSN5 | InterPro | 1107 | |||||||||||||
| UniProtKB:A0A8M3B2L0 | InterPro | 1306 | |||||||||||||
| UniProtKB:A0A8M3AVY2 | InterPro | 1251 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-178E6 | ZFIN Curated Data | |
| Contained in | BAC | CH211-93A19 | ZFIN Curated Data | |
| Contained in | BAC | CH211-209I22 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-206D21 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:171462 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001114721 (1) | 2148 nt | ||
| Genomic | RefSeq:NW_018394746 (1) | 389052 nt | ||
| Polypeptide | UniProtKB:A0A8M9QFV5 (1) | 1329 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Takeuchi, M., Yamaguchi, S., Sakakibara, M., Hayashi, T., Matsuda, K., Hara, Y., Tanegashima, C., Shimizu, T., Kuraku, S., Hibi, M. (2017) Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. The Journal of comparative neurology. 525(7):1558-1585
- Biswas, G., Kinoshita, S., Kono, T., Hikima, J.I., Sakai, M. (2015) Evolutionary evidence of tumor necrosis factor super family members in the Japanese pufferfish (Takifugu rubripes): Comprehensive genomic identification and expression analysis. Marine genomics. 22:25-36
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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