ZFIN is now using GRCz12tu for Genomic Data
Gene
adamts2a
- ID
- ZDB-GENE-070816-3
- Name
- ADAM metallopeptidase with thrombospondin type 1 motif, 2a
- Symbol
- adamts2a Nomenclature History
- Previous Names
-
- ADAMTS2/3 (1)
- adamts22
- adamts2
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable metalloendopeptidase activity. Acts upstream of or within cranial skeletal system development. Predicted to be active in extracellular matrix. Is expressed in several structures, including digestive system; eye; heart; pleuroperitoneal region; and thymus. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome; Ehlers-Danlos syndrome dermatosparaxis type; and stroke. Orthologous to human ADAMTS2 (ADAM metallopeptidase with thrombospondin type 1 motif 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Yao et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Ehlers-Danlos syndrome dermatosparaxis type | Alliance | Ehlers-Danlos syndrome, dermatosparaxis type | 225410 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001590 | Peptidase M12B, ADAM/reprolysin |
| Domain | IPR002870 | Peptidase M12B, propeptide |
| Domain | IPR010294 | ADAMTS/ADAMTS-like, Spacer 1 |
| Domain | IPR010909 | PLAC |
| Domain | IPR041645 | ADAMTS, cysteine-rich domain 2 |
| Domain | IPR045371 | ADAMTS/ADAMTS-like, cysteine-rich domain 3 |
| Family | IPR013273 | ADAMTS/ADAMTS-like |
| Family | IPR050439 | ADAMTS and ADAMTS-like |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
| Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | ADAMTS/ADAMTS-like | ADAMTS/ADAMTS-like, cysteine-rich domain 3 | ADAMTS/ADAMTS-like, Spacer 1 | ADAMTS and ADAMTS-like | ADAMTS, cysteine-rich domain 2 | Metallopeptidase, catalytic domain superfamily | Peptidase M12B, ADAM/reprolysin | Peptidase M12B, propeptide | PLAC | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q7A9 | InterPro | 159 | |||||||||||
| UniProtKB:A0A0R4ISF7 | InterPro | 1295 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adamts2-202
(1)
|
Ensembl | 3,772 nt | ||
| mRNA |
adamts2-203
(1)
|
Ensembl | 7,967 nt | ||
| ncRNA |
adamts2-002
(1)
|
Ensembl | 465 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers