Gene
edem3
- ID
- ZDB-GENE-070801-5
- Name
- ER degradation enhancer, mannosidase alpha-like 3
- Symbol
- edem3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in endoplasmic reticulum unfolded protein response; mannoprotein catabolic process; and ubiquitin-dependent glycoprotein ERAD pathway. Predicted to act upstream of or within carbohydrate metabolic process; endoplasmic reticulum mannose trimming; and mannose trimming involved in glycoprotein ERAD pathway. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human EDEM3 (ER degradation enhancing alpha-mannosidase like protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital disorder of glycosylation type IIv | Alliance | Congenital disorder of glycosylation, type IIv | 619493 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003137 | PA domain |
| Domain | IPR037322 | EDEM3, PA domain |
| Family | IPR001382 | Glycoside hydrolase family 47 |
| Family | IPR044674 | ER degradation-enhancing alpha-mannosidase-like protein 1/2/3 |
| Homologous_superfamily | IPR012341 | Six-hairpin glycosidase-like superfamily |
| Homologous_superfamily | IPR036026 | Seven-hairpin glycosidases |
| Homologous_superfamily | IPR046450 | PA domain superfamily |
Domain Details Per Protein
| Protein | Length | EDEM3, PA domain | ER degradation-enhancing alpha-mannosidase-like protein 1/2/3 | Glycoside hydrolase family 47 | PA domain | PA domain superfamily | Seven-hairpin glycosidases | Six-hairpin glycosidase-like superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BEF7
|
888 | |||||||
|
UniProtKB:A0A8N7T766
|
870 | |||||||
|
UniProtKB:A0A8M2BE98
|
872 | |||||||
|
UniProtKB:A0A8M3AV33
|
886 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance