Gene

abr

ID

ZDB-GENE-070705-146

Name

ABR activator of RhoGEF and GTPase

Symbol

abr Nomenclature History

Previous Names

im:6904863
si:ch211-253h3.1

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable GTPase activator activity; guanyl-nucleotide exchange factor activity; and protein serine/threonine kinase activity. Predicted to act upstream of or within intracellular signal transduction; positive regulation of GTPase activity; and protein phosphorylation. Predicted to be located in axon and dendritic spine. Predicted to be active in membrane. Orthologous to human ABR (ABR activator of RhoGEF and GTPase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6904863 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With abr Human Ortholog

No data available

Associated With abr Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain	IPR000008	C2 domain
Domain	IPR000198	Rho GTPase-activating protein domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR015123	Bcr-Abl oncoprotein oligomerisation
Domain	IPR037865	Active breakpoint cluster region-related protein, PH domain
Family	IPR037769	Abr/Bcr
Homologous_superfamily	IPR008936	Rho GTPase activation protein
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036481	Bcr-Abl oncoprotein oligomerisation domain superfamily

Domain Details Per Protein

Protein	Length	Abr/Bcr	Active breakpoint cluster region-related protein, PH domain	Bcr-Abl oncoprotein oligomerisation	Bcr-Abl oncoprotein oligomerisation domain superfamily	C2 domain	C2 domain superfamily	Dbl homology (DH) domain superfamily	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	PH-like domain superfamily	Pleckstrin homology domain	Rho GTPase-activating protein domain	Rho GTPase activation protein
UniProtKB:A0A8M2BFX1 InterPro	315
UniProtKB:A0A8M2BJA8 InterPro	814
UniProtKB:A0A8M6YYK4 InterPro	643
UniProtKB:A5WUN5 InterPro	324
UniProtKB:A0A8M1RSL2 InterPro	859
UniProtKB:A0A8M2BJC9 InterPro	1061