Gene
wrn
- ID
- ZDB-GENE-070702-2
- Name
- WRN RecQ like helicase
- Symbol
- wrn Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have 3'-5' DNA helicase activity and four-way junction helicase activity. Predicted to be involved in DNA geometric change; DNA metabolic process; and multicellular organism aging. Predicted to localize to chromosome; cytoplasm; and nucleoplasm. Human ortholog(s) of this gene implicated in Werner syndrome; breast cancer; coronary artery disease (multiple); diffuse scleroderma; and senile cataract. Orthologous to human WRN (WRN RecQ like helicase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Tian et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Werner syndrome | Alliance | Werner syndrome | 277700 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Werner syndrome | wrnsa34829/sa34829 | standard conditions | Tian et al., 2022 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR002121 | HRDC domain |
| Domain | IPR002562 | 3'-5' exonuclease domain |
| Domain | IPR011545 | DEAD/DEAH box helicase domain |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR018982 | RQC domain |
| Domain | IPR029491 | Helicase Helix-turn-helix domain |
| Domain | IPR032284 | ATP-dependent DNA helicase RecQ, zinc-binding domain |
| Family | IPR004589 | DNA helicase, ATP-dependent, RecQ type |
| Homologous_superfamily | IPR010997 | HRDC-like superfamily |
| Homologous_superfamily | IPR012337 | Ribonuclease H-like superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
| Homologous_superfamily | IPR036397 | Ribonuclease H superfamily |
| Homologous_superfamily | IPR044876 | HRDC domain superfamily |
Domain Details Per Protein
| Protein | Length | 3'-5' exonuclease domain | ATP-dependent DNA helicase RecQ, zinc-binding domain | DEAD/DEAH box helicase domain | DNA helicase, ATP-dependent, RecQ type | Helicase, C-terminal domain-like | Helicase Helix-turn-helix domain | Helicase superfamily 1/2, ATP-binding domain | HRDC domain | HRDC domain superfamily | HRDC-like superfamily | P-loop containing nucleoside triphosphate hydrolase | Ribonuclease H-like superfamily | Ribonuclease H superfamily | RQC domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AV58
|
1387 | ||||||||||||||||
|
UniProtKB:A0A0R4IT14
|
1387 |
Interactions and Pathways
No data available
Plasmids
No data available