Gene
rasgrp3
- ID
- ZDB-GENE-070424-82
- Name
- RAS guanyl releasing protein 3 (calcium and DAG-regulated)
- Symbol
- rasgrp3 Nomenclature History
- Previous Names
-
- zgc:162151
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have GTPase activator activity; calcium ion binding activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction and regulation of GTPase activity. Human ortholog(s) of this gene implicated in hypertension. Is expressed in blood island; central nervous system; and trunk vasculature. Orthologous to human RASGRP3 (RAS guanyl releasing protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Gomez et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
| Domain | IPR000651 | Ras-like guanine nucleotide exchange factor, N-terminal |
| Domain | IPR001895 | Ras guanine-nucleotide exchange factors catalytic domain |
| Domain | IPR002048 | EF-hand domain |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR020454 | Diacylglycerol/phorbol-ester binding |
| Family | IPR008937 | Ras-like guanine nucleotide exchange factor |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR023578 | Ras guanine nucleotide exchange factor domain superfamily |
| Homologous_superfamily | IPR036964 | Ras guanine-nucleotide exchange factor, catalytic domain superfamily |
| Homologous_superfamily | IPR046349 | C1-like domain superfamily |
Domain Details Per Protein
| Protein | Length | C1-like domain superfamily | Diacylglycerol/phorbol-ester binding | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Ras guanine-nucleotide exchange factor, catalytic domain superfamily | Ras guanine nucleotide exchange factor domain superfamily | Ras guanine-nucleotide exchange factors catalytic domain | Ras-like guanine nucleotide exchange factor | Ras-like guanine nucleotide exchange factor, N-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A4QNU6
|
708 | |||||||||||
|
UniProtKB:A0A8M2B4V9
|
708 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
rasgrp3-201
(1)
|
Havana | 3394 nt |
Interactions and Pathways
No data available
Plasmids
No data available