Gene
rxraa
- ID
- ZDB-GENE-070314-2
- Name
- retinoid X receptor, alpha a
- Symbol
- rxraa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable nuclear receptor activity and retinoic acid-responsive element binding activity. Predicted to be involved in several processes, including nervous system development; positive regulation of transcription by RNA polymerase II; and retinoic acid receptor signaling pathway. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including digestive system; nervous system; neural crest; optic vesicle; and segmental plate. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human RXRA (retinoid X receptor alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017629 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb857 | Allele with one delins | Unknown | Unknown | CRISPR | |
| ihb858 | Allele with one delins | Unknown | Unknown | CRISPR | |
| la021840Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021841Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021842Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028311Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028312Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mz50 | unknown | Unknown | Unknown | CRISPR | |
| xu086 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | TALEN | |
| xu0419Gt | Transgenic insertion | Intron 1 | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-rxraa | Zebrafish Nomenclature Committee | |
| CRISPR2-rxraa | Zebrafish Nomenclature Committee | |
| TALEN1-rxraa | Ma et al., 2020 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Domain | IPR021780 | Nuclear/hormone receptor activator site AF-1 |
| Family | IPR000003 | Retinoid X receptor/HNF4 |
| Family | IPR001723 | Nuclear hormone receptor |
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Domain Details Per Protein
| Protein | Length | Nuclear hormone receptor | Nuclear/hormone receptor activator site AF-1 | Nuclear hormone receptor family NR2 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Retinoid X receptor/HNF4 | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B855
|
495 | ||||||||
|
UniProtKB:A0A8M2B8E9
|
500 | ||||||||
|
UniProtKB:F1Q4V9
|
458 | ||||||||
|
UniProtKB:A2T929
|
430 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(actb2:LOXP-mCherry-STOP-LOXP-rxraa-EGFP) |
| 1 | Ma et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-242A9 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-275N23 | ZFIN Curated Data | |
| Encodes | EST | dq017629 | Bertrand et al., 2007 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001161551 (1) | 1377 nt | ||
| Genomic | GenBank:BX001031 (2) | 192207 nt | ||
| Polypeptide | UniProtKB:A0A8M2B8E9 (1) | 500 aa |
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Ding, Y., Lang, D., Yan, J., Bu, H., Li, H., Jiao, K., Yang, J., Ni, H., Morotti, S., Le, T., Clark, K.J., Port, J., Ekker, S.C., Cao, H., Zhang, Y., Wang, J., Grandi, E., Li, Z., Shi, Y., Li, Y., Glukhov, A.V., Xu, X. (2022) A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene. eLIFE. 11:
- Ding, Y., Wang, M., Bu, H., Li, J., Lin, X., Xu, X. (2022) An F0-based genetic assay in adult zebrafish for discovering modifier genes of an inherited cardiomyopathy. Disease models & mechanisms. 16(5):
- den Broeder, M.J., Ballangby, J., Kamminga, L.M., Aleström, P., Legler, J., Lindeman, L.C., Kamstra, J.H. (2020) Inhibition of methyltransferase activity of enhancer of zeste 2 leads to enhanced lipid accumulation and altered chromatin status in zebrafish. Epigenetics & chromatin. 13:5
- Ma, X., Zhu, P., Ding, Y., Zhang, H., Qiu, Q., Dvornikov, A.V., Wang, Z., Kim, M., Wang, Y., Lowerison, M., Yu, Y., Norton, N., Herrmann, J., Ekker, S.C., Hsiai, T.K., Lin, X., Xu, X. (2020) Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity. Science advances. 6:eaay2939
- Pípal, M., Legradi, J., Smutná, M., Kočí, T., Priebojová, J., Bláhová, L., Krauss, M., Hilscherová, K. (2020) Neurobehavioral effects of cyanobacterial biomass field extracts on zebrafish embryos and potential role of retinoids. Aquatic toxicology (Amsterdam, Netherlands). 228:105613
- Rodrigues, P., Cunha, V., Oliva-Teles, L., Ferreira, M., Guimarães, L. (2020) Norfluoxetine and venlafaxine in zebrafish larvae: Single and combined toxicity of two pharmaceutical products relevant for risk assessment. Journal of hazardous materials. 400:123171
- Tao, J., Bai, C., Chen, Y., Zhou, H., Liu, Y., Shi, Q., Pan, W., Dong, H., Li, L., Xu, H., Tanguay, R., Huang, C., Dong, Q. (2020) Environmental relevant concentrations of benzophenone-3 induced developmental neurotoxicity in zebrafish. The Science of the total environment. 721:137686
- Barbosa, M.A.G., Capela, R., Rodolfo, J., Fonseca, E., Montes, R., André, A., Capitão, A., Carvalho, A.P., Quintana, J.B., Castro, L.F.C., Santos, M.M. (2019) Linking chemical exposure to lipid homeostasis: A municipal waste water treatment plant influent is obesogenic for zebrafish larvae. Ecotoxicology and environmental safety. 182:109406
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