Gene

ncf2

ID

ZDB-GENE-070209-29

Name

neutrophil cytosolic factor 2

Symbol

ncf2 Nomenclature History

Previous Names

p67phox (1)
zgc:158405

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have Rac GTPase binding activity and superoxide-generating NADPH oxidase activator activity. Predicted to be involved in superoxide anion generation. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in Alzheimer's disease and autosomal recessive chronic granulomatous disease cytochrome b-positive type II. Orthologous to human NCF2 (neutrophil cytosolic factor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ncf2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive chronic granulomatous disease 2	Alliance	Chronic granulomatous disease 2, autosomal recessive	233710

Associated With ncf2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001452	SH3 domain
Domain	IPR034885	Neutrophil cytosol factor 2, PB1 domain
Domain	IPR034889	Neutrophil cytosol factor 2, SH3 domain
Domain	IPR035546	Neutrophil cytosol factor 2, SH3 domain 1
Homologous_superfamily	IPR011990	Tetratricopeptide-like helical domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Repeat	IPR019734	Tetratricopeptide repeat