Gene

celsr3

ID

ZDB-GENE-070122-3

Name

cadherin, EGF LAG seven-pass G-type receptor 3

Symbol

celsr3 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have G protein-coupled receptor activity and calcium ion binding activity. Involved in gamma-aminobutyric acid signaling pathway. Predicted to localize to integral component of membrane and plasma membrane. Is expressed in brain; eye; and muscle. Orthologous to human CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Lewis et al., 2011
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With celsr3 Human Ortholog

No data available

Associated With celsr3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000203	GPS motif
Conserved_site	IPR020894	Cadherin conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001791	Laminin G domain
Domain	IPR001879	GPCR, family 2, extracellular hormone receptor domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR002049	Laminin-type EGF domain
Domain	IPR002126	Cadherin-like
Domain	IPR017981	GPCR, family 2-like, 7TM
Domain	IPR032471	GAIN domain, N-terminal
Family	IPR000832	GPCR, family 2, secretin-like
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR015919	Cadherin-like superfamily
Homologous_superfamily	IPR036445	GPCR family 2, extracellular hormone receptor domain superfamily
Homologous_superfamily	IPR046338	GAIN domain superfamily

Domain Details Per Protein

Protein	Length	Cadherin conserved site	Cadherin-like	Cadherin-like superfamily	Concanavalin A-like lectin/glucanase domain superfamily	EGF-like calcium-binding domain	EGF-like domain	GAIN domain, N-terminal	GAIN domain superfamily	GPCR, family 2, extracellular hormone receptor domain	GPCR family 2, extracellular hormone receptor domain superfamily	GPCR, family 2-like, 7TM	GPCR, family 2, secretin-like	GPS motif	Laminin G domain	Laminin-type EGF domain
UniProtKB:A0A8M3B4X6 InterPro	3666
UniProtKB:A0A8M6YZZ5 InterPro	3587
UniProtKB:A0A8M3B208 InterPro	3656
UniProtKB:A0A8M3AV71 InterPro	3654

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	celsr3-202 (1) Ensembl	Havana	1323 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	celsr3-203 (1) Ensembl	Havana	1219 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	celsr3-204 (1) Ensembl	Havana	6195 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations