ZFIN is now using GRCz12tu for Genomic Data
Gene
ptpmt1
- ID
- ZDB-GENE-070112-272
- Name
- protein tyrosine phosphatase mitochondrial 1
- Symbol
- ptpmt1 Nomenclature History
- Previous Names
-
- im:7137979 (1)
- zgc:158719
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable phosphatidylglycerophosphatase activity; phosphatidylinositol-5-phosphate phosphatase activity; and protein serine/threonine phosphatase activity. Involved in glucose homeostasis. Acts upstream of or within mitochondrial respiratory chain complex I assembly; mitochondrial respiratory chain complex IV assembly; and regulation of cardiolipin metabolic process. Predicted to be located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in epilepsy. Orthologous to human PTPMT1 (protein tyrosine phosphatase mitochondrial 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7137979 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neurodevelopmental disorder with ataxia and brain abnormalities | Alliance | Neurodevelopmental disorder with ataxia and brain abnormalities | 621199 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000340 | Dual specificity phosphatase, catalytic domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR020422 | Dual specificity protein phosphatase domain |
| Family | IPR042165 | Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 |
| Family | IPR044596 | Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1-like |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
Domain Details Per Protein
| Protein | Additional Resources | Length | Dual specificity phosphatase, catalytic domain | Dual specificity protein phosphatase domain | Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 | Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1-like | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase-like | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BGB2 | InterPro | 119 | |||||||
| UniProtKB:A1L293 | InterPro | 183 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptpmt1-201
(1)
|
Ensembl | 1,118 nt | ||
| mRNA |
ptpmt1-203
(1)
|
Ensembl | 994 nt | ||
| ncRNA |
ptpmt1-003
(1)
|
Ensembl | 783 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers