Gene

kdm6al

ID

ZDB-GENE-070112-2002

Name

lysine (K)-specific demethylase 6A, like

Symbol

kdm6al Nomenclature History

Previous Names

utx1 (1)
utxl1
uty (1)
zgc:158313 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin DNA binding activity; and histone demethylase activity (H3-K27 specific). Involved in animal organ development; anterior/posterior pattern specification; and germ cell migration. Predicted to localize to MLL3/4 complex and nuclear chromatin. Human ortholog(s) of this gene implicated in Kabuki syndrome; acute lymphoblastic leukemia; and esophagus squamous cell carcinoma. Is expressed in blood island. Orthologous to human KDM6A (lysine demethylase 6A) and UTY (ubiquitously transcribed tetratricopeptide repeat containing, Y-linked).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kdm6al Human Ortholog

No data available

Associated With kdm6al Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003347	JmjC domain
Domain	IPR048560	Lysine-specific demethylase 6A/B-like, GATA-like
Domain	IPR048562	Lysine-specific demethylase 6A/B-like, C-terminal helical domain
Homologous_superfamily	IPR011990	Tetratricopeptide-like helical domain superfamily
Homologous_superfamily	IPR046941	Lysine-specific demethylase 6, GATA-like domain superfamily
Repeat	IPR019734	Tetratricopeptide repeat

Domain Details Per Protein

Protein	Length	JmjC domain	Lysine-specific demethylase 6A/B-like, C-terminal helical domain	Lysine-specific demethylase 6A/B-like, GATA-like	Lysine-specific demethylase 6, GATA-like domain superfamily	Tetratricopeptide-like helical domain superfamily	Tetratricopeptide repeat
UniProtKB:A1L1S9 InterPro	1311
UniProtKB:A0A8M2BG42 InterPro	1356

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	kdm6al-203 (1) Ensembl	Havana	5865 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	kdm6al-201 (1) Ensembl	Havana	4921 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	kdm6al-003 (1) Ensembl	Havana	208 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations