Gene
kcnk2a
- ID
- ZDB-GENE-061226-2
- Name
- potassium channel, subfamily K, member 2a
- Symbol
- kcnk2a Nomenclature History
- Previous Names
-
- kcnk2
- trek-1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Enables mechanosensitive monoatomic ion channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain. Orthologous to human KCNK2 (potassium two pore domain channel subfamily K member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Nasr et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Potassium channel domain | Two pore domain potassium channel | Two pore domain potassium channel, TREK |
|---|---|---|---|---|
|
UniProtKB:F1QAI2
|
426 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kcnk2a-201
(1)
|
Ensembl | 6,426 nt | ||
| mRNA |
kcnk2a-202
(1)
|
Ensembl | 1,568 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-152H14 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068214612 (1) | 1923 nt | ||
| Genomic | GenBank:BX936381 (1) | 156270 nt | ||
| Polypeptide | UniProtKB:F1QAI2 (1) | 426 aa |
- Park, S.J., Silic, M.R., Staab, P.L., Chen, J., Zackschewski, E.L., Zhang, G. (2024) Evolution of two-pore domain potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(8):722-749
- Wague, A., Joseph, T.T., Woll, K.A., Bu, W., Vaidya, K.A., Bhanu, N.V., Garcia, B.A., Nimigean, C.M., Eckenhoff, R.G., Riegelhaupt, P.M. (2020) Mechanistic insights into volatile anesthetic modulation of K2P channels. eLIFE. 9:
- Luo, J.J., Su, D.S., Xie, S.L., Liu, Y., Liu, P., Yang, X.J., Pei, D.S. (2018) Hypersensitive assessment of aryl hydrocarbon receptor transcriptional activity using a novel truncated cyp1a promoter in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(5):2814-2826
- Nasr, N., Faucherre, A., Borsotto, M., Heurteaux, C., Mazella, J., Jopling, C., Moha Ou Maati, H. (2018) Identification and characterization of two zebrafish Twik related potassium channels, Kcnk2a and Kcnk2b. Scientific Reports. 8:15311
- Loganathan, K., Moriya, S., Sivalingam, M., Ng, K.W., Parhar, I.S. (2017) Sequence and Localization of kcnk10a in the Brain of Adult Zebrafish (Danio rerio). Journal of chemical neuroanatomy. 86:92-99
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Gierten, J., Hassel, D., Schweizer, P.A., Becker, R., Katus, H.A., and Thomas, D. (2012) Identification and functional characterization of zebrafish K2P10.1 (TREK2) two-pore-domain K+ channels. Biomembranes. 1818(1):33-41
- Dong, X., Navratilova, P., Fredman, D., Drivenes, Ø., Becker, T.S., and Lenhard, B. (2010) Exonic remnants of whole-genome duplication reveal cis-regulatory function of coding exons. Nucleic acids research. 38(4):1071-1085
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