Gene

hfm1

ID

ZDB-GENE-061207-43

Name

helicase for meiosis 1

Symbol

hfm1 Nomenclature History

Previous Names

si:ch211-83f14.5

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have ATP binding activity and nucleic acid binding activity. Predicted to be involved in resolution of meiotic recombination intermediates. Human ortholog(s) of this gene implicated in premature ovarian failure. Orthologous to human HFM1 (helicase for meiosis 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hfm1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary ovarian insufficiency 9	Alliance	Premature ovarian failure 9	615724

Associated With hfm1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001650	Helicase, C-terminal domain-like
Domain	IPR004179	Sec63 domain
Domain	IPR011545	DEAD/DEAH box helicase domain
Domain	IPR014001	Helicase superfamily 1/2, ATP-binding domain
Family	IPR052247	Meiotic Crossover Helicase
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	DEAD/DEAH box helicase domain	Helicase, C-terminal domain-like	Helicase superfamily 1/2, ATP-binding domain	Meiotic Crossover Helicase	P-loop containing nucleoside triphosphate hydrolase	Sec63 domain	Winged helix DNA-binding domain superfamily	Winged helix-like DNA-binding domain superfamily
UniProtKB:A0A8M3APP0 InterPro	1045
UniProtKB:A0A8M9P056 InterPro	1461
UniProtKB:A0A8M3AX85 InterPro	1104

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	hfm1-202 (1) Ensembl	Ensembl		3,475 nt	Select Tool
ncRNA	hfm1-002 (1) Ensembl	Ensembl		493 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations